Professor Shafer is Professor of Anesthesiology, Perioperative and Pain Medicine (Adult MSD) at the Stanford University Medical Centre.
His professional interests are the clinical pharmacology of intravenous anesthetic drugs. This has led him to clinical studies of many of the intravenous opioids and hypnotics used in anesthetic practice.
However, his passion is not the drugs themselves, but rather the mathematical models that characterise drug behaviour. These include conventional pharmacokinetic and pharmacodynamic models, inverse models (used to drive target-controlled infusion systems), Bayesian models (used to handle model uncertainty), pharmacokinetic and pharmacodynamic models of drug interaction, models of receptor function that help elucidate mechanisms of drug action, and models that relate drug response to 'in silico' pharmacogenetics.